What do you want to do? If you want 'culture' and to explore the back alleys of one of the larger towns (Florence, Pisa or Siena) then stay anywhere inside one of these cities - preferably a hotel with car-parking. It is so much nicer to mooch about Siena/Pisa when the coachtours have decamped to Poggibonsi for the night. Even a Holiday Inn if you are on a budget - just be as central as possible in my opinion, and explore on foot.
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